Erythrose vs. Cancer

Click to open our publication with American Association for Cancer Research 101 Annual Meeting Erythrose Kill Cancer Cell in vitro and Inhibit Tumor Growth in vivo Summary of Erythrose Beat Cancer Erythrose (C4H8O4) is a sugar, 2/3 of glucose (C6H12O6). Not only erythrose has similar structure as glucose, but also it can be used for respiration as glucose, to be converted to CO2 and H2O (Batt et al. 1960). Erythrose-4-phosphate is in our body. (participates in Pentose Phosphate Pathway) Low toxicity: Erythrose’s mirror, erythrulose, toxicity is very low (NICNAS, Australia 2008). Cancer cell lines (lung, brain, breast, etc) die with ~4mM erythrose in 24hrs. Blood glucose reaches ~8 mM after meal, people with diabetes can tolerate 30mM for days. For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested. Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible Although erythrose is a sugar and existed in our body. Before proper testing, it should not be used for any one. It could be very dangerous without proper administration. The solution is very simple to understand. High school education is enough to understand. You just need common sense and logical think to understand that this is the only way we can beat cancer and save life. In general, it costs $1 billion to develop a drug. I have tried to raise fund. I have not got. I do not give up. But I can not deliver what I want without money. Life is priceless for everyone. Unfortunately, there is price tag I cannot afford. What is Cancer? According to National Cancer Institutes: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cell’s Life: cells >> divide >> differentiate to functional cell >> die. Cancer cells are our cells of our body. Cancer is a disease of undifferentiated dividing cells. Make cancer cell differentiate. Cancer is stopped!!! How Cell Survive? (http://hyperphysics.phy-astr.gsu.edu/hbase/biology/celres.html)

All cells of our body need energy to survive. There are two major energy processes, respiration and fermentation. Most cells in our body have the abilities of both fermentation and respiration. Glucose is major universal fuel of our body. In respiration, with oxygen participation, the cell converts glucose to carbon dioxide and water.In fermentation, without oxygen participation, the cell converts glucose to lactate. What is the difference between differentiated cell and cancer?(Heiden, et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324, 1029 (2009))

Since 1920’s, eighty years ago, people have known that normal cells mainly depend on respiration, while cancer cells mainly depend on fermentation. Not all cells mainly depending on fermentation divide. But all cells mainly depending on respiration do not divide. There are many and various reasons of cancer, genes, pathways, etc. The most profound, obvious, and significant difference is that differentiated cells (normal cells) mainly depend on respiration; while cancer cells mainly depend on fermentation. Dr. Warburg first reported this in 1920's. Not all cells, mainly powered by fermentation, divide. All cells, mainly powered by respiration, do not divide. Increasing cancer cell respiration will stop cancer cell dividing. How to increase cell respiration? Increasing mitochondria respiration. In human cell, respiration is in mitochondria. Mitochondria respiration is suppressed in cancer and other dividing cells. Cell division could be the reason of mitochondria suppression. Increasing non-mitochondria respiration. Aerobic bacteria without mitochondria have non-mitochondria respiration ability. Cancer cell has high oxidative stress, which has advantage to use non-mitochondrial respiration. Giving proper substance to cancer cell will destroy cancer. What does cancer like? Because cancer mainly depends on fermentation, cancer cells take more sugar than normal cell. Cancer likes sugar. PET Scan is based on this. What will happen if we give cancer a sugar, cancer has to use it for respiration? The sugar is erythrose. What is Erythrose?

Erythrose is a sugar, has 2/3 weight of glucose and similar structure. Erythrose is used for respiration. Feed rat radioactive erythrose, the radioactivity appears in respiratory carbon dioxide, in glucose or liver glycogen, and in urinary excretion (Batt et al. 1960). The final products are carbon dioxide and water. Erythrose-4-phosphate is in our body, participates in Pentose Phosphate Pathway In human health effects assessment with erythrulose, an isomer of erythrose, in rat, acute oral LD50 >2 g/kg bw, low toxicity; rat, repeat dose oral toxicity – 28 days, No Observed Effect Level (NOEL) is 1g/kg bw/day. It is non mutagenic to bacterial reverse mutation (NICNAS Australia, 2008). Cell Culture with Erythrose Cancer cell lines (lung, brain, breast, etc.) die with ~4mM (500mg/L) erythrose in 24 hrs. For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested.

Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible. Cancer cells die with enough erythrose, the concentration is well below similar small molecules our body can tolerate. Using Erythrose treat cancer is doable, and will be workable.